Select Publications

Tchalla EYI*, Betadpur*, Khalil A, Bhalla M and Bou Ghanem EN (2024) Sex-based difference in immune responses and efficacy of the pneumococcal conjugate vaccine. Journal of Leukocyte Biology. PMID: 39141715. *Equal contributions

• DOI: 10.1093/jleuko/qiae177

 

 

Bou Ghanem EN (2024) CHIPing away at immunity: the role of clonal hematopoiesis of indeterminate potential in bacterial pneumonia. Journal of Clinical Investigation. PMID: 38828722

• DOI: 10.1172/JCI181064

 

 

Simmons SR, Herring SE, Tchalla EYI, Lenhard A, Bhalla M and Bou Ghanem EN (2024) Activating A1 adenosine receptor signaling boosts early pulmonary neutrophil recruitment in aged mice in response to Streptococcus pneumoniae infection. Immunity & Ageing. PMID: 38840213

• DOI: 10.1186/s12979-024-00442-3

 

 

Bhalla M, Herring SE, Lenhard A, Wheeler JR, Aswad F, Klumpp K, Rebo J, Wang Y, Wilhelmsen K, Fortney K and Bou Ghanem EN (2024) The prostaglandin D2 antagonist Asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae. Infection & Immunity. PMID: 38629842

• DOI: 10.1128/iai.00522-23

 

 

Herring SE, Mao S, Bhalla M, Tchalla EYI, Kramer JM, Bou Ghanem EN (2022) Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling. PLoS Pathogens. PMID: 36374941.

• DOI: 10.1371/journal.ppat.1010700

 

 

Lenhard A, Joma BH, Siwapornchai N, Hakansson AP, Leong JM, Bou Ghanem EN (2022) A Mouse Model for Transition of Streptococcus pneumoniae From Colonizer to Pathogen Upon Viral Co-infection Recapitulates Age-exacerbated Illness. JoVE. PMID: 36279528.

• DOI: 10.3791/64419

 

 

Simmons SR, Tchalla EYI, Bhalla M and Bou Ghanem EN (2022) The age-driven decline in neutrophil function contributes to the reduced efficacy of the pneumococcal conjugate vaccine in old hosts. Frontiers In Cellular & Infection Microbiology. PMID: 35402289

• DOI: 10.3389/fcimb.2022.849224

 

 

Vidal JE, Bou Ghanem EN, Wu X, Wu K, Bai G, Hammerschmidt S. (2022) Editorial: Transmission, colonization, and molecular pathogenesis of pneumococcus. Frontiers In Cellular & Infection Microbiology. PMID: 36176577.

• DOI: 10.3389/fcimb.2022.1028047

 

 

Bhalla M, Nayerhoda R, Tchalla EYI, Abamonte A, Park D, Simmons SR, Pfeifer BA and Bou Ghanem EN (2021) Liposomal Encapsulation of Polysaccharides (LEPS) as an Effective Vaccine Strategy to Protect Aged Hosts Against S. pneumoniae Infection. Frontiers In Aging. PMID: 35291600.

• DOI: 10.3389/fragi.2021.798868

 

 

Bhalla M, Heinzinger LR, Morenikeji OB, Marzullo B, Thomas BN paper here and Bou Ghanem EN (2021) Transcriptome profiling reveals CD73 and age-driven changes in neutrophil responses against Streptococcus pneumoniae.  Infection & Immunity. PMID: 34310891.

• DOI: 10.1128/IAI.00258-21

 

 

Joma BH, Siwapornchai N, Vanguri VK, Shrestha A, Roggensack SE, Davidson BA, Tai AK, Hakansson AP, Meydani SN, Leong JM and Bou Ghanem EN (2021) A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity Upon Viral Infection and Advanced Age. Infection & Immunity. PMID: 34031128.

• DOI: 10.1128/IAI.00471-20

 

 

Bhalla M, Simmons SR, Tchalla EYI, and Bou Ghanem EN (2021) Testing anti-pneumococcal antibody function using bacteria and primary neutrophils. Methods in Molecular Biology. PMID: 32959268.

• DOI: 10.1007/978-1-0716-0795-4_33

 

 

Walkowski W, Bassett J, Bhalla M, Pfeifer BA and Bou Ghanem EN (2021) Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease. Vaccines. PMID: 34199398.

• DOI: 10.3390/vaccines9060589

 

 

Simmons SR, Bhalla M, Herring SE, Tchalla EYI and Bou Ghanem EN (2021) Older but not wiser: The age-driven changes in neutrophil responses during pulmonary infections. Infection & Immunity. PMID: 33495271.

• DOI: 10.1128/IAI.00653-20

 

 

Bhalla M, Simmons SR, Abamonte A, Herring SE, Roggensack SE and Bou Ghanem EN (2020) Extracellular adenosine signaling reverses the age-driven decline in the ability of neutrophils to kill S. pneumoniae. Aging Cell. PMID: 32790148

• DOI: 10.1111/acel.13218

 

 

Nayerhoda R, Park D, Jones C, Bou Ghanem EN, Pfeifer BA (2020) Extended polysaccharide analysis within the Liposomal Encapsulation of Polysaccharides system. Materials (Basel). PMID: 32722578.

• DOI: 10.3390/ma13153320

 

 

Tchalla EYI, Bhalla M, Wohlfert EA, and Bou Ghanem EN (2020) Neutrophils are required during immunization with the pneumococcal conjugate vaccine for protective antibody responses and host defense against infection. Journal of Infectious Diseases.. PMID: 32391562.

• DOI: 10.1093/infdis/jiaa242

 

 

Siwapornchai N, Lee JN, Bhalla M, Tchalla EYI, Roggensack SE, Leong JM and Bou Ghanem EN (2020) Extracellular adenosine enhances the ability of neutrophils to kill S. pneumoniae by blunting IL-10 production. Journal of Leukocyte Biology. PMID: 32017200.

• DOI: 10.1002/JLB.4MA0120-115RR

 

 

Bou Ghanem EN (2019) Adenosine in host defense against bacterial pneumonia: friend or foe? mSphere. PMID:31292232.

• DOI: 10.1128/mSphere.00326-19

 

 

Bhalla M, Yeoh JH, Lamneck C, Herring SE, Tchalla EYI, Heinzinger LR, Leong JM and Bou Ghanem EN (2019) A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of patelet-activating factor receptor. Cellular Microbiology. PMID:31709673.

• DOI: 10.1111/cmi.13141